In the 1990’s, a Spanish microbiology PhD graduate student, Francisco Mojica, figured out the function of these repeating sequences by first noting that they were palindromes, readable the same way in both directions and named them Clustered Regularly Interspaced Short Palindromic Repeats from which the acronym CRISPR was devised.Īt the same time, the book is following the early life, professional career and thinking development of the key player in this whole book, Dr. The real story begins in the 1980’s in Japan where PhD microbiology graduate student Yoshizumi Ishino noted five homologous sequences of 29 nucleotides arranged in repeating sequence in the genome of the bacterium E. The book chases both the quest for the sequencing of full genetic codes and what they do in humans and other organisms. Here is a book that tells the complete story of genetic editing from the biochemistry laboratory of Rosalind Franklin, in the 50’s to Jennifer Doudna’s 2020 lab and the development of COVID-19 vaccines.įranklin’s groundbreaking X-ray diffraction photography in the early 1950’s gave Watson and Crick the key to the structure of the DNA molecule which sets up the life story of Jennifer Doudna’s research.
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